Behavioral Neuroscience, lecture on Aplysia and its behavior
USD Department of Biology
Behavioral Neuroscience
Aplysia Behavior
Sensory Stimulation of Siphon Withdrawl
Motor Output driving Siphon Withdrawal
Conditioning & Memory
Aplysia Siphon and Gill text:Kandel pages 1248-1257
Acetylcholine (ACh)
Aplysia and Siphon Withdrawl
Siphon Withdrawl Circuitry
end     Acronyms/Abbreviations     Syllabus
Siphon Withdrawal
III. Sensory Stimulation of Siphon Withdrawal 			

	A. Siphon-gill withdrawal reflex Sensory neurons
		1. Cell bodies in abdominal ganglion
			a. 24
		2. mechanoreceptors in the siphon
			a. touch causes distention of receptor membrane
				i. stretch receptors
				ii. opens Na+ channels
					(1) leads to depolarization and action potential
		3. axon terminals in abdominal ganglion
			a. excitatory
				i. Neurotransmitter = Glutamate (Glu)
				ii. Glu binds AMPA receptors
					(1) often paired with NMDA receptors
			b. monosynaptic
				i. on 13 motor neurons
					(1) projecting to muscles in
					    gill or siphon
			c. also terminals on interneurons (i.e. disynaptic)
				i. excitatory - may be Glu 
				ii. inhibitory - may be GABA 
				iii. modulatory - serotonin (5-hydroxytryptamine, 5-HT)
	B. Tail-siphon reflex seonsory neurons
		1. Somata in left & right pleural ganglia
			a. 200 neurons, bilaterally symmetrical
		2. mechanoreceptors in tail
		3. monosynaptic excitatory Glu-AMPA terminals
			a. on 3 motor neurons
				i. in adjacent ipsilateral pedal ganglia
					(1) left pleural to left pedal
				ii. project to muscles in the tail
		4. excitatory and inhibitory interneurons
			a. activate motor neurons in the abdominal ganglion
				i. project to muscles on siphon
			b. and pedal ganglia

IV. Glutamate

V. Motor output driving Siphon Withdrawal