Summers Lab

Laboratory of Molecular Neuropsychoecoendochemistry

Investigators                     Research                    Publications                     Cliff Summers                     Contact Us                    

Research Interests
Our laboratory focuses on the impact of social and environmental stressors on molecular, neural and endocrine responses to influence adaptive behavior and activities like social interaction, learning, developing social rank relationships, depression, anxiety, biological rhythms, reproduction, and coping with stress. Of special interest are how and why individuals differ, and how responses are characterized temporally. The investigations include the connection between molecular, neural and endocrine responses and variability in the magnitude and way in which individuals respond to and cope with stress behaviorally. We have recently developed a new model that includes aggression, learned escape and conditioned submission. We are interested in elucidating the mechanisms by which experience modulates the responsiveness of neural and hormonal stress responses. We focus on the relationships of molecular genetics, physiology and anatomy with behavior, ecology and evolution.
Selected Lab Publications          A complete listing of Lab publications
Arendt DH, J Hassell, Hao Li, JK Achua, DJ Guarnieri, RJ DiLeone, PJ Ronan, and CH Summers 2014 Anxiolytic function of the orexin 2 / 
	hypocretin A receptor in the basolateral amygdala. Psychoneuroendocrinology 40C: 17-26

Carpenter RE and CH Summers 2009 Learning strategies during fear conditioning Neurobiology of Learning and Memory 91: 415-423

Korzan WJ, E Höglund, MJ Watt, GL Forster, Ø Øverli, JL Lukkes and CH Summers 2007 Memory of opponents is more potent than visual sign 
	stimuli after social hierarchy has been established. Behav Brain Res 183: 31-42

Smith JP, MA Prince, JK Achua, JM Robertson, RT Anderson, PJ Ronan, and CH Summers 2016 Intensity of anxiety is modified via complex 
	integrative stress circuitries. Psychoneuroendocrinology 63: 351-361

Staton CD, JDW Yaeger, DD Khalid, F Haroun, BS Fernandez, JS Fernandez, BK Summers, TR Summers, M Sathyanesan, SS Newton, CH Summers, 2018
	Orexin 2 receptor stimulation enhances resilience, while orexin 2 inhibition promotes susceptibility, to social stress, anxiety and
	depression. Neuropharmacology 143: 79-94.

Summers CH, JDW Yaeger, CD Staton, DH Arendt, TR Summers 2018 Orexin/hypocretin receptor modulation of anxiolytic and antidepressive responses
	during social stress and decision-making: potential for therapy. Brain Research: In Press 

Summers TR, TL Summers,  RE Carpenter,  JP Smith,  SL Young,  B Meyerink,  TZ Orr,  DH Arendt, and  CH Summers 2017 Learning and CRF-induced 
	indecision during escape and submission in rainbow trout during socially aggressive interactions in the Stress-Alternatives Model
	Frontiers in Neuroscience 11: 515: 1-13

Waters RP, M Rivalan, D Bangasser, J Deussing, M Ising, SK Wood, F Holsboer, CH Summers 2015 Evidence for the role of 
	corticotropin-releasing factor in major depression disorder Neuroscience & Biobehavioral Reviews 63: 351-361

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